Numbers are everywhere, and supporting difficulties in numerical cognition (e.g., mathematical learning disability (MLD)) in a timely, effective manner is critical for their daily use. To date, only low-efficacy cognitive-based interventions are available. The extensive data on the neurobiology of MLD have increased interest in brain-directed approaches. The overarching goal of this study protocol is to provide the scientific foundation for devising brain-based and evidence-based treatments in children and adolescents with MLD. In this double-blind, between-subject, sham-controlled, randomized clinical trial, transcranial random noise stimulation (tRNS) plus cognitive training will be delivered to participants. Arithmetic, neuropsychological, psychological, and electrophysiological measures will be collected at baseline (T0), at the end of the interventions (T1), one week (T2) and three months later (T3). We expect that tRNS plus cognitive training will significantly improve arithmetic measures at T1 and at each follow-up (T2, T3) compared with placebo and that such improvements will correlate robustly and positively with changes in the neuropsychological, psychological, and electrophysiological measures. We firmly believe that this clinical trial will produce reliable and positive results to accelerate the validation of brain-based treatments for MLD that have the potential to impact quality of life.

Boosting numerical cognition in children and adolescents with mathematical learning disabilities by a brain-based intervention: A study protocol for a randomized, sham-controlled clinical trial / Lazzaro, G.; Battisti, A.; Varuzza, C.; Celestini, L.; Pani, P.; Costanzo, F.; Vicari, S.; Kadosh, R. C.; Menghini, D.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 18:20(2021). [10.3390/ijerph182010969]

Boosting numerical cognition in children and adolescents with mathematical learning disabilities by a brain-based intervention: A study protocol for a randomized, sham-controlled clinical trial

Pani P.;
2021

Abstract

Numbers are everywhere, and supporting difficulties in numerical cognition (e.g., mathematical learning disability (MLD)) in a timely, effective manner is critical for their daily use. To date, only low-efficacy cognitive-based interventions are available. The extensive data on the neurobiology of MLD have increased interest in brain-directed approaches. The overarching goal of this study protocol is to provide the scientific foundation for devising brain-based and evidence-based treatments in children and adolescents with MLD. In this double-blind, between-subject, sham-controlled, randomized clinical trial, transcranial random noise stimulation (tRNS) plus cognitive training will be delivered to participants. Arithmetic, neuropsychological, psychological, and electrophysiological measures will be collected at baseline (T0), at the end of the interventions (T1), one week (T2) and three months later (T3). We expect that tRNS plus cognitive training will significantly improve arithmetic measures at T1 and at each follow-up (T2, T3) compared with placebo and that such improvements will correlate robustly and positively with changes in the neuropsychological, psychological, and electrophysiological measures. We firmly believe that this clinical trial will produce reliable and positive results to accelerate the validation of brain-based treatments for MLD that have the potential to impact quality of life.
2021
EEG; Evidence-based medicine; Specific learning disorders; Transcranial electrical stimulation; Adolescent; Brain; Child; Cognition; Double-Blind Method; Humans; Quality of Life; Randomized Controlled Trials as Topic; Learning Disabilities; Transcranial Direct Current Stimulation
01 Pubblicazione su rivista::01a Articolo in rivista
Boosting numerical cognition in children and adolescents with mathematical learning disabilities by a brain-based intervention: A study protocol for a randomized, sham-controlled clinical trial / Lazzaro, G.; Battisti, A.; Varuzza, C.; Celestini, L.; Pani, P.; Costanzo, F.; Vicari, S.; Kadosh, R. C.; Menghini, D.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 18:20(2021). [10.3390/ijerph182010969]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1611376
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